Uv spectrophotometric simultaneous determination of. The recommended maximum daily dosage of sulbactam is 4 g. Rodent studies are reassuring, revealing no evidence of teratogenicity or iugr despite the use of doses higher than those used clinically. This study shows that current cefoperazonesulbactam dosage regimens may result in inadequate plasma concentrations in cirrhotic patients. Use of cefoperazonesulbactam in neonates fahri ovali, tugba gursoy, ilkay sari, demet divrikli and alev aktas neonatal intensive care unit, zeynep kamil maternity and childrens training and research hospital, istanbul, turkey abstract background. The dose for patients weighing at least 40 kg is expressed as the total of ampicillin content plus sulbactam content in a constant 2. Sulbactam 2 gday 1 g q 12 h cefoperazone sulbactam combination in the treatment of urinary tract infections. Sulbactam is available in combination with cefoperazone in a fixed 1. The maximum daily dosage of sulbactam in pediatrics should not exceed 80 mgkgday. Cefoperazonesulbactam combination in the treatment of. If more than 80 mgkgday of cefoperazone activity are necessary, additional cefoperazone should be administered reconstitution sulbactamcefoperazone is available in 1. Coamoxiclav and cefoperazone sulbactam have also been used for.
The mean sd duration of cs treatment and dosage were 10. The role of cefoperazonesulbactam combination when coadministered with other antibiotics for the treatment of severe infections was also noticed 9,10. Renal impairment dosage regimens of sulbactamcefoperazone should be adjusted in. Because of its broad spectrum of activity, most infections can be treated adequately with this antibiotic. Use of bacticidcs from tablets, pregnancy, lactation in childrens and special precautions for bacticidcs from tablets, prices of bacticidcs from tablets. When cefoperazone and sulbactam are used in combination, adjustment of the dosing regimen for patients with estimated creatinine clearance of less than 30 ml. Cefoperazonesulbactam is used in children but there are limited data on its usage in neonates.
Cefoperazone sodium 750mg, sulbactam 750mg pfizer vial n. Sulbactam sodium contains a betalactam ring and irreversibly binds to betalactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of. The choice of regimen, with dosage adjustment according to renal function, was determined by the patients clinicians. Cefoperazonesulbactam therapeutic drug monitoring in. An increased v ss d also was observed for sulbactam. Sulbactam cefoperazone is generally well tolerated. In the assay, the principle peak in the chromatogram obtained with the sample solution should. Cefoperazone sulbactam is an antibiotic medicine which comes in the form of a vial containing cefoperazone sodium equivalent to mg of cefoperazone and sulbactam sodium equivalent to 500 mg sulbactam. Doses should be administered every 12 hours in equally divided doses. Sulbactam sodium is the sodium salt form of sulbactam, a betalactam with weak antibacterial property. Greenberg rn1, reilly pm, weinandt wj, bollinger m, kennedy dj.
Cefoperazone crosses the human placenta, but to a lower degree than ceftizoxime. Cefoperazone sodium is a semisynthetic broadspectrum cephalosporin antibiotic and sulbactam sodium is a derivative of the basic penicillin. Superiority of cefoperazonesulbactam also was demonstrated for this endpoint, with significantly more subjects achieving continued resolution at the 30day followup than in the comparator group p 0. Single vial in a monocarton, prescription at rs 225piece in bengaluru, karnataka. Pharmacokinetics and pharmacodynamics of cefoperazone. Pdf cefoperazonesulbactam for treatment of intraabdominal. Cefoperazonesulbactam in the treatment of serious intra.
Cefoperazone is excreted in small amounts into human breast milk and has a relative infant dose of dosage of sulbactamcefoperazone may be increased up to 12 g of the 1. For iv infusion, each vial should be reconstituted with suitable amount of sterile water for inj, normal saline, 5% dextrose in water, and then diluted to 20 ml using the same diluent followed by admin over 1560 minutes. There was marked improvement in his clinical status but the thrombocytopenia persisted. Cefoperazone and cefoperazonesulbactam johns hopkins. Cefoperazone sulbactam is one of the most commonly used blblis in china. In a previous small trial, which was a randomized, doubleblind, controlled study, we found that a low dose of cefoperazone sulbactam 25 mgkgday of cefoperazone plus cotrimoxazole is as effective as a high dose of ceftazidime plus cotrimoxazole.
Learn how to pronounce the drugs name, its indications, dosage, how to take, when. Pdf neonates are at high risk for nosocomial infections due to. Drug concentrations in the serum and cerebrospinal fluid of patients. Therefore, cefoperazonesulbactam might be effective in the treatment of severe melioidosis. Cefoperazonesulbactam for treatment of intraabdominal. Jul 01, 2001 therefore, cefoperazone sulbactam might be effective in the treatment of severe melioidosis. About 0% of these are phosphate, 0% are water treatment chemicals, and 1% are petroleum additives. Cefoperazonesulbactam for treatment of intraabdominal infections. Cefoperazone sodium 500mg, sulbactam 250mg ultramark.
Cefoperazone sodium injection indications, dosage, side. Cefoperazone sulbactam combination in the treatment of urinary tract infections. The present results indicated that a higher dose or intrathecal injection might be required for intracranial infection when pathogens with mics. In addition, it demonstrates synergistic activity up to 4fold reduction in the minimum inhibitory concentrations for the combination versus those for each component in a variety of organisms. Comparison of empirical therapy with cefoperazonesulbactam or a carbapenem for bloodstream infections due to esblproducing enterobacteriaceae. May 10, 2018 cefoperazone sulbactam is an antibiotic medicine which comes in the form of a vial containing cefoperazone sodium equivalent to mg of cefoperazone and sulbactam sodium equivalent to 500 mg sulbactam. In clinical trials, most children received oral antimicrobials after initial treatment with iv ampicillin sulbactam. Steadystate pharmacokinetics of cefoperazone and sulbactam. Cefoperazone sodium 500mg, sulbactam 500mg prg pharma. High dose parenteral treatment should be given for a minimum of 10 days and preferably at least 14 days in systemic infections and the switch to oral treatment only made when there is clear evidence of clinical improvement. Cefobactam injection 1 gm and 2 gm cefoperazone as sodium im iv sulbactam as sodium 1. Cefoperazone and cefoperazonesulbactam is a topic covered in the johns hopkins abx guide to view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Cefoperazone and sulbactam1 fda orange book approved.
They received a daily dose of 24g of sulbactamcefoperazone by intravenous injection over a. He was diagnosed as a case of bacterial pneumonia complicated with sepsis and thrombo cytopenia. To identify changes in cefoperazonesulbactam penetration into cerebrospinal fluid csf after craniotomy and to investigate preliminarily. A 17yearold male reported to chest outpatient department. Superiority of cefoperazonesulbactam also was demonstrated for this. Validated hptlc method for simulteneous determination of. In this study, we evaluated and compared the clinical efficacy of cefoperazone sulbactam with that of a carbapenem in the treatment of bloodstream infections bsis caused by esblproducing enterobacteriaceae. For intravenous or intramuscular use food and drug. Cefoperazone has a broad spectrum of activity and has been used to target bacteria responsible for causing infections of the respiratory and urinary tract, skin, and the female genital tract. The cefoperazone and sulbactam concentrations in csf were highest. Sulbactam sodium cefaperazone sodium combination is available as a dry powder for reconstitution in a 1. He was prescribed cefoperazone sulbactam and amikacin for the treatment of infection.
Pdf tracking cefoperazonesulbactam resistance development. Get best price and read about company and get contact details and address. It is one of few cephalosporin antibiotics effective in treating pseudomonas bacterial infections which are otherwise resistant to these antibiotics. Cefoperazone is a medicine available in a number of countries worldwide. Randomized, doubleblind, controlled study of cefoperazone. A simple, accurate and precise hptlc method for simultaneous estimation of cefoperazone sodium. Ampicillin sulbactam dosage guide with precautions.
Guide to antimicrobial therapy 2017 cover malaysian society of. They received a daily dose of 24g of sulbactamcefoperazone by intravenous injection over a period of 35 or 60 minutes once or twice daily. Sulbactam sodium contains a betalactam ring and irreversibly binds to betalactamase at or near its active site, thereby blocking enzyme activity and preventing metabolism of other betalactam antibiotics. List of approved drug products containing cefoperazone and sulbactam1 in the fda orange book on. Renal impairment dosage regimens of sulbactamcefoperazone should be adjusted in patients with a. On microbiologic outcomes, cefoperazonesulbactam had higher success rates than ceftazidimeamikacinmetronidazole 92.
Ampicillin and sulbactam for injection dry powder is freely soluble in aqueous diluents to yield pale yellow to yellow solutions containing ampicillin sodium and sulbactam sodium equivalent to 250 mg ampicillin per ml and 125 mg sulbactam per ml. Before using cefoperazone sulbactam injection, inform your doctor about your current list of medications, over the counter products e. Cefoperazone sodium and sulbactam sodium in combined dosage form mr. In severe or refractory infections the daily dosage may be increased to 8g i. Compared with data from healthy volunteers, cefoperazone exhibited a decreased cl and increased v ss d and t 12. Pdf cefoperazonesulbactam has been shown to be efficacious for the treatment of infections.
The disposition of cefoperazonesulbactam is altered in this group of patients. Cefoperazone and sulbactam injection actiza pharmaceutical. In a previous small trial, which was a randomized, doubleblind, controlled study, we found that a low dose of cefoperazonesulbactam 25 mgkgday of cefoperazone plus cotrimoxazole is as effective as a high dose of ceftazidime plus cotrimoxazole. Neonates are at high risk for nosocomial infections due to multidrugresistant pathogens.
Nov 16, 2007 dosage regimens of sulbactamcefoperazone should be adjusted in patients with marked decreased in renal function creatinine clearance of less than 20mlmin to compensate for the reduced clearance of sulbatam. Bactonis injection contains cefoperazone and sulbactam. Comparison of empirical therapy with cefoperazonesulbactam. Cefoperazone sodium 1g, sulbactam 1g pfizer vial 500. Cefoperazonesulbactam has been shown to be efficacious for the treatment of. Sulbactam sodium is a derivative of the basic penicillin nucleus.
In severe or refractory infections, the daily dosage of sulbactamcefoperazone may be increased up to 8 g of the 1. Effects of missed dosage of cefoperazone sodium take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose. The purpose of the present study was therefore to evaluate the use of. Clinical experience with cefoperazonesulbactam indicates that it is unlikely to impair a patients ability to drive or use machinery. Apr 20, 2007 the primary objective is to collect data on treatment outcomes clinical and microbiological cure, safety and tolerability of treatment with cefoperazone sulbactam in patients with serious intraabdominal and hepatobiliary infections in slovakia. If more than 80 mgkgday of cefoperazone activity are necessary, additional cefoperazone should be administered reconstitution sulbactam cefoperazone is available in 1. Superimposed reversible thrombocytopenia secondary to. Pdf use of cefoperazonesulbactam in neonates researchgate. We recommend monitoring the c min of cefoperazonesulbactam to ensure efficacy of cefoperazonesulbactam treatment. Sulbactamcefoperazone was administered to 16 cases biliary tract infections 5 cases, two of them with bacteremia. Ceftriaxonesulbactam is as effective and welltolerated as cefoperazone sulbactam for the treatment of intermediate and severe bacterial.
Clinical experience with cefoperazone sulbactam indicates that it is unlikely to impair a patients ability to drive or use machinery. Dose levels used are 250 mg cefoperazone sodium per infected quarter once or 100 mg cefoperazone dihydrate per infected quarter twice with a dosing interval of. Pharmacokinetics of cefoperazonesulbactam in plasma and. On discontinuing cefoperazonesulbactam therapy the. Cefoperazone sulbactam injection uses, sideeffects. A wide variety of cefoperazone sodium and sulbactam sodium options are available to you, such as grade standard. Cefoperazonesulbactam combination in the treatment of urinary tract infections. Some health conditions may make you more susceptible to the sideeffects of the drug.
On microbiologic outcomes, cefoperazone sulbactam had higher success rates than ceftazidimeamikacinmetronidazole 92. Cefoperazonesulbactam was administered as a single dose in a randomized crossover fashion. Superiority of cefoperazone sulbactam also was demonstrated for this endpoint, with significantly more subjects achieving continued resolution at the 30day followup than in the comparator group p 0. The usual adult dose of the combination is 2 to 4 gday i. Saira mulla shri jjt university,vidyanagari, churu,jhunjhunu road,chudela,districtjhunjhunu, rajasthan333001 abstract. Cefoperazonesulbactam sulperazon is a coformulation with sulbactam. High serum and bile levels of cefobid are attained after a single dose of the drug.
Results from a randomized, parallel group study in india. A multicentre clinical study on the injection of ceftriaxonesulbactam. Cefoperazone sulbactam is used for bacterial infection of the respiratory tract, peritonitis, urinary tract infection, endometritis, pelvic inflammatory disease, septicemia and other conditions. In clinical trials, most children received oral antimicrobials after initial treatment with iv ampicillinsulbactam. The placental transfer of cefoperazone is about 33% of a dose, but concentrations in breast milk are low. Cefoperazone plus sulbactam an overview sciencedirect. Cefoperazone and cefoperazonesulbactam johns hopkins abx guide. A list of us medications equivalent to cefoperazone is available on the website. Cefoperazone and sulbactam for injection contains 90% to 110% of cefoperazone and 90% to 110% of sulbactam of stated amount. The majority of adverse events are of mild or moderate severity and are tolerated with continued treatment.
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